Baytril
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Introduction
1. Baytril 10% Oral Solution
2. Baytril 2.5% Oral Solution
3. Baytril 2.5% Solution for Injection
4. Baytril 5% Solution for Injection
5. Baytril Flavour Tabs
6. Baytril Max Solution for Injection
7. Baytril Piglet Doser
Presentation
1. Baytril 10% Oral Solution
A clear aqueous oral solution containing as active ingredient 100 mg/ml enrofloxacin, and 14 mg/ml benzyl alcohol as a preservative.
2. Baytril 2.5% Oral Solution
A ready to use clear aqueous oral solution containing as active ingredient 25 mg/ml enrofloxacin, and 14 mg/ml benzyl alcohol (Ph.Eur.) as a preservative.
3. Baytril 2.5% Solution for Injection
A ready to use sterile aqueous injectable solution containing 25 mg/ml enrofloxacin and 30 mg/ml n-butyl alcohol as a preservative.
4. Baytril 5% Solution for Injection
Baytril 5% Solution for Injection is a clear sterile light yellow solution for injection containing as active ingredient enrofloxacin 50 mg/ml with 30 mg/ml n-butyl alcohol as a preservative.
5. Baytril Flavour Tabs
Light brown to brown, slightly marbled, round coloured flavoured tablets containing 15 mg enrofloxacin for oral administration to dogs and cats, and 50 mg or 150 mgenrofloxacin for oral administration to dogs.
6. Baytril Max Solution for Injection
A ready to use sterile aqueous injectable solution containing as active ingredient 100 mg/ml enrofloxacin, with 20 mg/ml benzyl alcohol and 30 mg/ml butyl alcohol as preservatives.
7. Baytril Piglet Doser
Baytril Piglet Doser is a clear aqueous solution for oral use containing as active ingredient, 5 mg/ml enrofloxacin with 14 mg/ml benzyl alcohol as a preservative.
Uses
Enrofloxacin is a synthetic, broad spectrum antimicrobial substance, belonging to the fluoroquinolone group of antibiotics. It is bactericidal in action and effective against many gram positive and gram negative bacteria and mycoplasmas.
1. Baytril 10% Oral Solution
Cattle
Diseases of the respiratory and alimentary tract of bacterial or mycoplasmal origin (e.g. pasteurellosis, mycoplasmosis, coli-bacillosis, coli-septicaemia and salmonellosis) and secondary bacterial infections subsequent to viral infections (e.g. viral pneumonia) where clinical experience, supported where possible by sensitivity testing of the causal organism, indicates enrofloxacin as the drug of choice.
Treatment of local signs (inflammation, milk quality and yield) associated with peracute/acute mastitis in lactating dairy cattle caused by E. coli, where herd history and previous sensitivity testing indicate enrofloxacin as the drug of choice.
Pigs
Diseases of the respiratory and alimentary tract of bacterial or mycoplasmal origin (e.g. pasteurellosis, mycoplasmosis, coli-bacillosis, coli-septicaemia and salmonellosis), and multifactorial diseases such as atrophic rhinitis and enzootic pneumonia, where clinical experience, supported where possible by sensitivity testing of the causal organism, indicates enrofloxacin as the drug of choice.
2. Baytril 2.5% Oral Solution
Baytril 2.5% Oral Solution is indicated for use in calves for the treatment of infections of the respiratory and alimentary tract of bacterial or mycoplasmal origin (e.g. pasteurellosis, mycoplasmosis, coli-bacillosis and salmonellosis), where clinical experience, supported where possible by sensitivity testing of the causal organism, indicates enrofloxacin as the drug of choice.
Baytril 2.5% Oral Solution may also be used in exotic animals (small mammals, reptiles and avian species) for the treatment of bacterial infections of the alimentary and respiratory tracts where clinical experience, supported where possible by sensitivity testing of the causal organism, indicates enrofloxacin as the drug of choice.
3. Baytril 2.5% Solution for Injection
Enrofloxacin is a synthetic, broad spectrum antimicrobial substance, belonging to the fluoroquinolone group of antibiotics. It is bactericidal in action with activity against many gram positive and gram negative bacteria and mycoplasmas.
The product is for use in dogs and cats in the treatment of bacterial infections of the alimentary, respiratory and urogenital tracts, skin, secondary wound infections and otitis externa where clinical experience, supported where possible by sensitivity testing of the causal organism indicates enrofloxacin as the drug of choice.
The product may also be used in exotic animals (small mammals, reptiles and avian species) for the treatment of bacterial infections of the alimentary and respiratory tracts where clinical experience, supported where possible by sensitivity testing of the causal organism, indicates enrofloxacin as the drug of choice.
4. Baytril 5% Solution for Injection
Baytril 5% Solution for Injection is a clear sterile light yellow solution for injection containing as active ingredient enrofloxacin 50 mg/ml with 30 mg/ml n-butyl alcohol as a preservative.
5. Baytril Flavour Tabs
Enrofloxacin is a synthetic, broad spectrum antimicrobial substance, belonging to the fluoroquinolone group of antibiotics. It is bactericidal in action and effective against many gram positive and gram negative bacteria and mycoplasmas.
The product is for use in dogs and cats in the treatment of bacterial infections of the alimentary, respiratory and urogenital tracts, skin, secondary wound infections and otitis externa where clinical experience, supported where possible by sensitivity testing of the causal organism, indicates enrofloxacin as the drug of choice.
6. Baytril Max Solution for Injection
Enrofloxacin is a synthetic, broad spectrum antimicrobial substance, bactericidal in action with efficacy against a wide range of gram positive and gram negative bacteria and mycoplasmas.
Cattle
The product is indicated for the treatment of bovine respiratory disease associated with Mannheimia haemolytica, Pasteurella multocida, Histophilus somnus and Mycoplasma species, where clinical experience, supported where possible, by sensitivity testing of the causal organism, indicates enrofloxacin as the drug of choice.
7. Baytril Piglet Doser
The product is for use in the treatment of diseases of the respiratory and alimentary tracts of bacterial or mycoplasmal origin (e.g. pasteurellosis, mycoplasmosis, coli-bacillosis, coli-septicaemia and salmonellosis), and multifactorial diseases such as atrophic rhinitis and enzootic pneumonia, where clinical experience, supported where possible by sensitivity testing of the causal organism, indicates enrofloxacin as the drug of choice.
Dosage & administration
1. Baytril 10% Oral Solution
Baytril tablets: 1 x 5 mg enrofloxacin per kg bodyweight (bw) daily: 15 mg tablet: 1 tablet per 3 kg bw 50 mg tablet: 1 tablet per 10 kg bw 150 mg tablet : 1 tablet per 30 kg bw Baytril 2.5 % Injectable solution: 0.2 ml per 1 kg bw daily. 0.2 ml is equivalent to 5 mg enrofloxacin Baytril 5% and 10% injectable: The dose is 2.5 - 5mg per kg bw or 5 - 10ml 5% injectable solution (resp. 2,5 to 5 ml 10% injectable solution per 100 kg bw Baytril Max (Baytril 100) 10% injectable solution: 7.5 mg / kg bw is equal to 7.5 ml per 100kg bw Baytril 0,5% oral solution (piglet-doser): 1 pump stroke (1ml) per 2 kg bw is equivalent to 2.5mg per kg bw. In severe cases of respiratory disease this dose can be doubled. Baytril 2,5% oral solution: 5ml per 50 kg In severe cases of respiratory disease this dose can be doubled. Baytril 10% oral solution: the dosage is 10mg per kg bw in chicken and turkeys. This equals drinking water concentrations of 50 to 100ml 10% oral solution per 100 litres of drinking water. Duration of treatment and withdrawal periods according to national registrations.
2. Baytril 2.5% Oral Solution
Calves
Baytril 2.5% Oral Solution is administered via the milk, milk replacer, electrolyte solution or water. The dose rate is 2.5 mg per kg body weight (5 ml per 50 kg) daily for 3 days. This rate may be doubled to 5 mg per kg (10 ml per 50 kg) for 5 days for salmonellosis and complicated respiratory disease. Medicated fluids should be made up immediately prior to provision on a daily basis.
Exotic animals
See Table 1.
The dose rates given are for guidance only. Veterinary surgeons are advised to contact the company prior to use to discuss the particulars of each individual case.
Table 1: Dosage for Baytril 2.5% Oral Solution | ||||
Species | Dosage | Route | Dose Frequency | Treatment period |
Small mammals | 5 mg enrofloxacin per kg bodyweight (0.2 ml/kg bw) | Orally diluted in water | Twice daily | 7 days |
Reptiles | 5 mg enrofloxacin per kg bodyweight (0.2 ml/kg bw) | Orally diluted in water | 24-48 hour intervals | 6 days |
Birds (excluding chickens and turkeys) | 10 mg enrofloxacin per kg bodyweight (0.4 ml/kg bw) | Orally diluted in water | Twice daily | 7 days |
For direct administration by gavage, dilutions of 1 part Baytril 2.5% Oral Solution to 4 parts water are recommended. If the product is to be given via the drinking water, concentrations of between 50 and 200 ppm should be considered as suitable working dilutions. Concentrations in excess of 250 ppm should be avoided as precipitation may occur. The dilution should be made on a daily basis, immediately prior to provision, preferably in a glass container. The use of 0.5 ml (100 unit) insulin syringe should be considered for the withdrawal of the very small volumes of Baytril 2.5% Oral Solution required for dilution prior to administration.
Treatment may be initiated with Baytril 2.5% Injection and maintained with Baytril 2.5% Oral Solution.
Medicated fluids should be made up immediately prior to provision on a daily basis.
Use during pregnancy and lactation
In the absence of data on its use in some exotic species, caution should be used when prescribing during these periods and a careful risk/benefit assessment made.
3. Baytril 2.5% Solution for Injection
Dogs and cats
1 ml of product per 5 kg bodyweight (5 mg enrofloxacin per kg bodyweight) by subcutaneous injection once daily for 3 to 5 days. Treatment may be initiated with the injection and maintained orally with Baytril Flavour Tablets.
Exotic animals
See Table 1.
The dose rates given below are for guidance only. Veterinary surgeons are advised to contact the company prior to use to discuss the particulars of each individual case. The use of a 0.5 ml (100 unit) insulin syringe should be considered for administration of the very small volumes required by some species of small mammals (mice, gerbils etc).
Table 1: Dosage for Baytril 2.5% Solution for Injection | ||||
Species | Dosage | Route | Dose Frequency | Treatment period |
Small mammals | 5 mg/kg bw (0.2 ml/kg) | s.c. | Twice daily | 7 days |
Reptiles | 5 mg/kg bw (0.2 ml/kg) | i.m. | 24-48 hour intervals | 6 days |
Avian spp | 10 mg/kg bw (0.4 ml/kg) | i.m. | Twice daily | 7 days |
Treatment may be initiated with the injection and maintained with Baytril 2.5% Oral Solution.
Use during pregnancy and lactation
There is no restriction on the use of this product during pregnancy and lactation of the bitch and queen.
In the absence of data on its use in some exotic species, caution should be used when prescribing during these periods and a careful risk/benefit assessment made.
Not for use in dogs less than one year of age or in exceptionally large breeds of dog with a longer growth period under 18 months of age.
Not for use in cats less than 8 weeks of age.
Baytril 2.5% Injection should not be used for prophylaxis.
Dogs:Not for use in dogs less than 1 year of age or in exceptionally large breeds of dog with a longer growth period under 18 months of age.
In dogs enrofloxacin may affect articular cartilage during the period of rapid growth.
Occasionally skin reactions have been seen after administration to kennelled greyhounds.
Cats:Retinotoxic effects including blindness can occur when the recommended dose is exceeded.
Exotic animals:Muscle bruising after injection in reptiles and birds has been reported occasionally.
Do not exceed the recommended dosage.
In dogs enrofloxacin may affect articular cartilage during the period of rapid growth.
Local tissue reactions may occasionally occur at the injection site. Normal sterile precautions should be taken.
Do not exceed the recommended dose. In accidental overdose there is no antidote and treatment should be symptomatic.
In target animal studies, cats have been shown to suffer ocular damage after receiving doses of more than 15mg/kg once daily for 21 consecutive days. Doses of 30mg/kg given once daily for 21 consecutive days have been shown to cause irreversible ocular damage. At 50mg/kg given once daily for 21 consecutive days, blindness can occur.
Not for use in exotic animals or birds intended for human consumption.
User safety:
Baytril 2.5% Solution for Injection is an alkaline solution. Wash any splashes from skin or eyes immediately with water
Do not eat, drink or smoke whilst using the product.
Care should be taken to avoid accidental self-injection. If accidental injection occurs, seek medical advice immediately.
4. Baytril 5% Solution for Injection
Enrofloxacin is a synthetic, broad spectrum antimicrobial substance, belonging to the fluoroquinolone group of antibiotics. It is bactericidal in action and effective against many gram positive and gram negative bacteria and mycoplasmas.
Dogs and Cats
The product is indicated in the treatment of bacterial infections of the alimentary, respiratory and urogenital tracts, skin, secondary wound infections and otitis externa where clinical experience, supported where possible by sensitivity testing of the causal organism, indicates enrofloxacin as the drug of choice.
Cattle
Diseases of the respiratory and alimentary tract of bacterial or mycoplasmal origin (e.g. pasteurellosis, mycoplasmosis, coli-bacillosis, coli-septicaemia and salmonellosis) and secondary bacterial infections subsequent to viral conditions (e.g. viral pneumonia) where clinical experience, supported where possible by sensitivity testing of the causal organism, indicates enrofloxacin as the drug of choice.
Pigs
Diseases of the respiratory and alimentary tract of bacterial or mycoplasmal origin (e.g. pasteurellosis, actinobacillosis, mycoplasmosis, coli-bacillosis, coli-septicaemia and salmonellosis) and mulifactorial diseases such as atrophic rhinitis and enzootic pneumonia, where clinical experience, supported where possible by sensitivity testing of the causal organism, indicates enrofloxacin as the drug of choice.
5. Baytril Flavour Tabs
Dogs and cats
The dose rate of enrofloxacin is 5 mg/kg given orally once daily or as a divided dose twice daily for 3 to 10 days with or without food. Treatment may be initiated with Baytril 5% Solution for Injection or Baytril 2.5% Solution for Injection and maintained with the tablets.
The daily dose is achieved as follows:
Cats and small dogs: Baytril 15 mg – 1 tablet per 3 kg bodyweight
Medium dogs: Baytril 50 mg – 1 tablet per 10 kg bodyweight
Large dogs: Baytril 150 mg – 1 tablet per 30 kg bodyweight
Use during pregnancy and lactation
There is no restriction on the use of this product during pregnancy and lactation.
6. Baytril Max Solution for Injection
Dosage rate
A single dose of 7.5 mg enrofloxacin per kg bodyweight (7.5 ml per 100 kg bodyweight)
Method of administration
The product is administered subcutaneously.
Not more than 15 ml should be administered at one subcutaneous injection site.
Use during pregnancy and lactation
Not restricted
7. Baytril Piglet Doser
Dose rate is 1.5 – 5 mg enrofloxacin/kg bodyweight daily. The contents of Baytril Piglet Doser are administered orally using the dosing pump. 1 pump stroke delivers 1 ml.
For piglets up to 3 kg bodyweight – 1 ml once daily for 3 to 5 days
For piglets 3 kg up to 10 kg bodyweight – 3 ml once daily for 3 to 5 days
Price comparison
Contra-indications, warnings, etc.
1. Baytril 10% Oral Solution
Baytril 10% Oral Solution should not be used for prophylaxis. Official and local antimicrobal policies should be taken into account when the product is used. Fluoroquinolones should be reserved for the treatment of clinical conditions which have responded poorly, or are expected to respond poorly, to other classes of antimicrobials. Wherever possible, fluoroquinolones should only be used based on susceptibility testing. Use of the product deviating from the instructions given on the SPC may increase the prevalence of bacteria resistant to the fluoroquinolones and may decrease the effectiveness of treatment with other quinolones due to the potential for cross resistance. During the period of rapid growth, enrofloxacin may affect articular cartilage. Do not exceed the recommended dose. In accidental overdose there is no antidote and treatment should be symptomatic. For animal treatment only. This product should not be used for the treatment of poultry (chickens and turkeys). Baytril 10% Oral Solution is indicated for these animals. Not for use in exotic animals or birds intended for human consumption. User safety Wear impervious gloves when handling the product. Wash any splashes from skin or eyes immediately with water. Wash hands and exposed skin after use. Do not eat, drink or smoke whilst using the product. Withdrawal Periods Calves must not be slaughtered for human consumption during treatment. Calves may be slaughtered for human consumption only after 8 days from the last treatment.
2. Baytril 2.5% Oral Solution
Baytril 2.5% Oral Solution should not be used for prophylaxis.
Consult the Technical Services Department of Bayer prior to use in exotic animals.
Official and local antimicrobal policies should be taken into account when the product is used.
Fluoroquinolones should be reserved for the treatment of clinical conditions which have responded poorly, or are expected to respond poorly, to other classes of antimicrobials.
Wherever possible, fluoroquinolones should only be used based on susceptibility testing.
Use of the product deviating from the instructions given on the SPC may increase the prevalence of bacteria resistant to the fluoroquinolones and may decrease the effectiveness of treatment with other quinolones due to the potential for cross resistance.
During the period of rapid growth, enrofloxacin may affect articular cartilage. In the absence of data on its use in some exotic species, caution should be used when prescribing during these periods and a careful risk/benefit assessment made.
Do not exceed the recommended dose. In accidental overdose there is no antidote and treatment should be symptomatic.
For animal treatment only.
This product should not be used for the treatment of poultry (chickens and turkeys). Baytril 10% Oral Solution is indicated for these animals.
Not for use in exotic animals or birds intended for human consumption.
User safety
Wear impervious gloves when handling the product.
Wash any splashes from skin or eyes immediately with water.
Wash hands and exposed skin after use.
Do not eat, drink or smoke whilst using the product.
Withdrawal Periods
Calves must not be slaughtered for human consumption during treatment. Calves may be slaughtered for human consumption only after 8 days from the last treatment.
Not for use in exotic animals or birds intended for human consumption.
3. Baytril 2.5% Solution for Injection
ot for use in dogs less than one year of age or in exceptionally large breeds of dog with a longer growth period under 18 months of age.
Not for use in cats less than 8 weeks of age.
Baytril 2.5% Injection should not be used for prophylaxis.
Dogs:Not for use in dogs less than 1 year of age or in exceptionally large breeds of dog with a longer growth period under 18 months of age.
In dogs enrofloxacin may affect articular cartilage during the period of rapid growth.
Occasionally skin reactions have been seen after administration to kennelled greyhounds.
Cats:Retinotoxic effects including blindness can occur when the recommended dose is exceeded.
Exotic animals:Muscle bruising after injection in reptiles and birds has been reported occasionally.
Do not exceed the recommended dosage.
In dogs enrofloxacin may affect articular cartilage during the period of rapid growth.
Local tissue reactions may occasionally occur at the injection site. Normal sterile precautions should be taken.
Do not exceed the recommended dose. In accidental overdose there is no antidote and treatment should be symptomatic.
In target animal studies, cats have been shown to suffer ocular damage after receiving doses of more than 15mg/kg once daily for 21 consecutive days. Doses of 30mg/kg given once daily for 21 consecutive days have been shown to cause irreversible ocular damage. At 50mg/kg given once daily for 21 consecutive days, blindness can occur.
Not for use in exotic animals or birds intended for human consumption.
User safety:
Baytril 2.5% Solution for Injection is an alkaline solution. Wash any splashes from skin or eyes immediately with water
Do not eat, drink or smoke whilst using the product.
Care should be taken to avoid accidental self-injection. If accidental injection occurs, seek medical advice immediately.
4. Baytril 5% Solution for Injection
Dogs under 1 year of age should not be treated with Baytril as damage to the articular cartilage may occur during the period of rapid growth, specifically in large breeds of dog. As a precaution very large breeds of dog should not be treated with Baytril until they are 18 months of age because of their longer growth period. Not for use in cats less than 8 weeks of age.
Baytril 5% Injection should not be used for prophylaxis.
Cats: Retinotoxic effects including blindness can occur when the recommended dose is exceeded. In accidental overdose there is no antidote and treatment should be symptomatic.
In target animal studies, cats have been shown to suffer ocular damage after receiving doses of more than 15mg/kg once daily for 21 consecutive days. Doses of 30mg/kg given once daily for 21 consecutive days have been shown to cause irreversible ocular damage. At 50mg/kg given once daily for 21 consecutive days, blindness can occur.
Dogs: Occasionally skin reactions have been seen after administration to kennelled greyhounds.
Do not exceed the recommended dosage.
Repeat injections should be made at different sites.
Official and local antimicrobial policies should be taken into account when the product is used.
Fluoroquinolones should be reserved for the treatment of clinical conditions which have responded poorly, or are expected to respond poorly, to other classes of antimicrobials.
Whenever possible, fluoroquinolones should only be used based on susceptibility testing.
Use of the product deviating from the instructions given in the SPC may increase the prevalence of bacteria resistant to the fluoroquinolones and may decrease the effectiveness of treatment with other quinolones due to the potential for cross resistance.
During the period of rapid growth, enrofloxacin may affect articular cartilage.
Local tissue reactions may occur at the injection site. Normal sterile precautions should be taken.
Withdrawal Periods
MEAT
Cattle: Animals must not be slaughtered for human consumption during treatment. Animals may be slaughtered for human consumption only after 14 days from the last treatment.
Pigs: Animals must not be slaughtered for human consumption during treatment. Animals may be slaughtered for human consumption only after 10 days from the last treatment.
MILK
Not to be used in animals producing milk for human consumption.
User Safety: Baytril 5% Solution for Injection is an alkaline solution. Wash any splashes from skin and eyes immediately with water.
Do not eat, drink or smoke whilst using the product.
Care should be taken to avoid accidental self-injection. If accidental injection occurs, seek medical advice immediately.
5. Baytril Flavour Tabs
Not recommended for use in cats less than 8 weeks of age.
The product should not be used for prophylaxis.Do not exceed the recommended dose. In accidental overdosage vomiting, diarrhoea, and CNS/behavioural changes may occur. There is no antidote and treatment should be symptomatic.
In cats, retinotoxic effects including blindness can occur when the recommended dose is exceeded.
Not for use in dogs less than 1 year of age or in exceptionally large breeds of dog with a longer growth period under 18 months of age, as articular cartilage may be affected during the period of rapid growth.
6. Baytril Max Solution for Injection
Baytril Max 10% Solution for Injection should not be used for prophylaxis.
Official and local antimicrobial policies should be taken into account when the product is used.
Fluoroquinolones should be reserved for the treatment of clinical conditions which have responded poorly, or are expected to respond poorly, to other classes of antimicrobials.
Whenever possible, fluoroquinolones should only be used based on susceptibility testing.
Use of the product deviating from the instructions given in the SPC may increase the prevalence of bacteria resistant to the fluoroquinolones and may decrease the effectiveness of treatment with other quinolones due to the potential for cross resistance.
Do not exceed the recommended dose. In accidental overdose there is no antidote and treatment should be symptomatic
User safety
Baytril Max is an alkaline solution.
Wash any splashes from skin or eyes immediately with water.
Do not eat, drink or smoke whilst using the product.
Care should be taken to avoid self-injection. If accidental self-injection occurs, seek medical advice immediately.
Withdrawal Periods
Animals must not be slaughtered for human consumption during treatment. Cattle may be slaughtered for human consumption only after 14 days from the injection. Milk for human consumption must not be taken during treatment. Milk for human consumption may only be taken from cattle after 84 hours (i.e. 7 milkings) from the last treatment.
7. Baytril Piglet Doser
Baytril Piglet Doser
Contra-indications, warnings, etc
The product should not be used for prophylaxis.
Official and local antimicrobial policies should be taken into account when the product is used.
Fluoroquinolones should be reserved for the treatment of clinical conditions which have responded poorly, or are expected to respond poorly, to other classes of antimicrobials.
Whenever possible, fluoroquinolones should only be used based on susceptibility testing.
Use of the product deviating from the instructions given in the SPC may increase the prevalence of bacteria resistant to the fluoroquinolones and may decrease the effectiveness of treatment with other quinolones due to the potential for cross resistance.
Do not exceed the recommended dose. In accidental overdose there is no antidote and treatment should be symptomatic .
Consumer Safety
Withdrawal Period: Piglets: Meat: 10 days
User Safety
Wear impervious gloves when handling the product.
Wash any splashes from skin or eyes immediately with water.
Wash hands and exposed skin after use.
Do not eat, drink or smoke while using the product.
Environmental Safety
Any unused product or waste material should be disposed of in accordance with national requirements.
Pharmaceutical precautions
1. Baytril 10% Oral Solution
Do not store above 25°C.
Store in a dry place.
Following withdrawal of the first dose use the product within 28 days. Discard unused material.
Any unused product or waste material should be disposed of in accordance with national requirements.
2. Baytril 2.5% Oral Solution
Do not store above 25°C.
Store in a dry place.
Keep out of reach of children.
Following withdrawal of the first dose use the product within 28 days.
Discard unused material.
Any medicated liquid remaining 24 hours after preparation must be discarded.
Any unused product and containers should be disposed of in accordance with national requirements.
3. Baytril 2.5% Solution for Injection
Do not store above 25°C.
Following withdrawal of the first dose, use the product within 28 days. Discard unused material.
Any unused product or waste material should be disposed of in accordance with national requirements.
4. Baytril 5% Solution for Injection
Do not store above 25°C.
Store in a dry place.
Following withdrawal of the first dose, use the product within 28 days. Discard unused material.
Unused product or waste material should be disposed of in accordance with current practice for pharmaceutical waste under national waste disposal regulations.
5. Baytril Flavour Tabs
Do not store above 25°C.
Store in a dry place.
Unused product or waste material should be disposed of in accordance with current practice for pharmaceutical waste under national waste disposal regulations.
6. Baytril Max Solution for Injection
Store below 25°C. Do not freeze. Following withdrawal of the first dose, use product within 28 days. Discard if visibly contaminated.
Any unused product and containers should be disposed of in accordance with national requirements.
7. Baytril Piglet Doser
Do not store above 25°C.
Following withdrawal of the first dose, use the product within 28 days.
Discard unused material.
Packaging quantities
1. Baytril 10% Oral Solution
White high density polyethylene bottles with a polypropylene screw cap containing 100 ml.
2. Baytril 2.5% Oral Solution
White high density polyethylene bottles with a polypropylene screw cap containing 100 ml.
3. Baytril 2.5% Solution for Injection
50 ml amber type II glass vials with a grey teflonised butyl rubber stopper or a chlorobutyl PTFE stopper.
4. Baytril 5% Solution for Injection
100 ml amber type II glass vials with a grey teflonised butyl rubber stopper or a chlorobutyl PTFE stopper.
5. Baytril Flavour Tabs
Strips of 10 tablets in blister foil supplied in dispensing cartons containing 100 tablets.
6. Baytril Max Solution for Injection
Individually packed multi-dose bottles of 100 ml amber type I glass with siliconised grey rubber butyl stopper.
7. Baytril Piglet Doser
White high density polyethylene bottles with polypropylene screw cap containing 100 ml.
Dosing Device: a polypropylene/polyethylene/stainless steel pump dispensing 1ml
Further information
1. Baytril 10% Oral Solution
Enrofloxacin is a synthetic, broad spectrum antimicrobial substance, belonging to the fluoroquinolone group of antibiotics.
Enrofloxacin is bactericidal in action with activity against a wide range of Gram positive and Gram negative bacteria and mycoplasmas. The mechanism of action of the quinolones is unique among antimicrobials - they act primarily to inhibit bacterial DNA gyrase, an enzyme responsible for controlling the supercoiling of bacterial DNA during replication. Resealing of the double stranded helix is inhibited resulting in irreversible degradation of the chromosomal DNA. The fluoroquinolones also possess activity against bacteria in the stationary phase by an alteration of the permeability of the outer membrane phospholipid cell wall.
Molecular resistance to fluoroquinolones has been observed to arise from two principal sources, (i) alteration to DNA gyrase or topoisomerase IV and (ii) alterations in drug permeability of the bacterial cell. Both mechanisms lead to a reduced susceptibility of the bacteria to fluoroquinolones. Clinical resistance is dependent on several mutations accumulating in a step-wise manner. The pharmacokinetics of enrofloxacin are such that oral and parenteral administration leads to similar serum levels. Enrofloxacin possesses a high distribution volume. Tissue levels 2-3 higher than that found in the serum, have been demonstrated in laboratory animals and target species. Organs in which high levels can be expected are the lungs, liver, kidney, skin, bone and lymphatic system. Enrofloxacin also distributes into the cerebrospinal fluid, the aqueous humour and the foetus in pregnant animals.
After an intravenous dose of 5 mg enrofloxacin per kg body weight (bw) to lactating dairy cattle, the total systemic exposure over the dosing interval of 24 h was at 7.1 mg*h/L. In cattle serum, approximately 30% of drug exposure (2.31 mg*h/L) consisted of ciprofloxacin, the active metabolite of enrofloxacin. The drug was well distributed into the body compartments (Venro = 1.5 L/kg, Vcipro = 8.51 L/kg). Total body clearance was 0.71 L/h/kg. In milk, most of drug activity consisted of ciprofloxacin. Overall drug concentrations peaked at 4.1 mg/kg two hours after treatment. Overall drug exposure over 24 h was
22.1 mg*h/L. The actives were eliminated from milk with a mean exposure half-life of 2.8 h.
2. Baytril 2.5% Oral Solution
Enrofloxacin is a synthetic, broad spectrum antimicrobial substance, belonging to the fluoroquinoline group of antibiotics.
Enrofloxacin is bactericidal in action with activity against Gram positive and Gram negative bacteria and mycoplasmas. The mechanism of action of the quinolones is unique among antimicrobials - they act primarily to inhibit bacterial DNA gyrase, an enzyme responsible for controlling the supercoiling of bacterial DNA during replication. Resealing of the double stranded helix is inhibited resulting in irreversible degradation of the chromosomal DNA. The fluoroquinolones also possess activity against bacteria in the stationary phase by an alteration of the permeability of the outer membrane phospholipid cell wall.
The pharmacokinetics of enrofloxacin are such that both oral and parenteral administration leads to similar serum levels. Enrofloxacin possesses a high distribution volume. Tissue levels 2-3 times higher than found in the serum, have been demonstrated in laboratory animals and target species. Organs in which high levels can be expected are the lungs, liver, kidney, skin, bone and lymphatic system. Enrofloxacin also distributes into the cerebrospinal fluid, the aqueous humour and the foetus in pregnant animals.
3. Baytril 2.5% Solution for Injection
Enrofloxacin is a synthetic, broad spectrum antimicrobial substance, belonging to the fluoroquinoline group of antibiotics.
Enrofloxacin is bactericidal in action with activity against Gram positive and Gram negative bacteria and mycoplasmas. The mechanism of action of the quinolones is unique among antimicrobials - they act primarily to inhibit bacterial DNA gyrase, an enzyme responsible for controlling the supercoiling of bacterial DNA during replication. Resealing of the double stranded helix is inhibited resulting in irreversible degradation of the chromosomal DNA. The fluoroquinolones also possess activity against bacteria in the stationary phase by an alteration of the permeability of the outer membrane phospholipid cell wall.
The pharmacokinetics of enrofloxacin in dogs and cats are such that oral and parenteral administration leads to similar serum levels. Enrofloxacin possesses a high distribution volume. Tissue levels 2-3 times higher than that found in the serum have been demonstrated in laboratory animals and target species. Organs in which high levels can be expected are the lungs, liver, kidney, skin, bone and lymphatic system. Enrofloxacin also distributes into the cerebrospinal fluid, the aqueous humour and the foetus in pregnant animals.
4. Baytril 5% Solution for Injection
Enrofloxacin is a synthetic, broad spectrum antimicrobial substance, belonging to the fluoroquinoline group of antibiotics.
Enrofloxacin is bactericidal in action with activity against Gram positive and Gram negative bacteria and mycoplasmas. The mechanism of action of the quinolones is unique among antimicrobials - they act primarily to inhibit bacterial DNA gyrase, an enzyme responsible for controlling the supercoiling of bacterial DNA during replication.
Resealing of the double stranded helix is inhibited resulting in irreversible degradation of the chromosomal DNA. The fluoroquinolones also possess activity against bacteria in the stationary phase by an alteration of the permeability of the outer membrane phospholipid cell wall.
The pharmacokinetics of enrofloxacin in dogs and cats are such that oral and parenteral administration leads to similar serum levels. Enrofloxacin possesses a high distribution volume. Tissue levels 2-3 times higher than that found in the serum have been demonstrated in laboratory animals and target species. Organs in which high levels can be expected are the lungs, liver, kidney, skin, bone and lymphatic system. Enrofloxacin also distributes into the cerebrospinal fluid, the aqueous humour and the foetus in pregnant animals.
5. Baytril Flavour Tabs
The pharmacokinetics of enrofloxacin are such that oral and parenteral administration lead to similar serum levels. Enrofloxacin possesses a high distribution volume. Tissue levels 2–3 times higher than that found in the serum have been demonstrated in laboratory animals and target species. Organs in which high levels can be expected are the lungs, liver, kidney, skin, bone, and lymphatic system. Enrofloxacin also distributes into the C.S.F., the aqueous humour, and the foetus in pregnant animals.
In target animal studies, cats have been shown to suffer ocular damage after receiving doses of more than 15 mg/kg once daily for 21 consecutive days. Doses of 30 mg/kg given once daily for 21 consecutive days have been shown to cause irreversible ocular damage. At 50 mg/kg given once daily for 21 consecutive days, blindness can occur.
6. Baytril Max Solution for Injection
Enrofloxacin is a synthetic, broad spectrum antimicrobial substance belonging to the fluoroquinolone group of antibiotics.
It is bactericidal in action with activity against many Gram positive and Gram negative bacteria and mycoplasmas. The mechanism of action of the quinolones is unique among antimicrobials - they act primarily to inhibit bacterial DNA gyrase, an enzyme responsible for controlling the supercoiling of bacterial DNA during replication. Resealing of the double stranded helix is inhibited resulting in irreversible degradation of the chromosomal DNA. The fluoroquinolones also possess activity against bacteria in the stationary phase by an alteration of the permeability of the outer membrane phospholipid cell wall but are inactive against strict anaerobes
The pharmacokinetics of enrofloxacin are such that oral and parenteral administration leads to similar serum levels. Enrofloxacin is lipid soluble and amphoteric and possesses a high distribution volume. Tissue levels 2-3 higher than that found in the serum, have been demonstrated in laboratory animals and target species. Organs in which high levels can be expected are the lungs, liver, kidney, skin, bone and lymphatic system. Enrofloxacin also distributes into the cerebrospinal fluid, the aqueous humour and the foetus in pregnant animals.
After subcutaneous administration of 7.5 mg/kg the mean peak plasma concentration is 0.8 µg/ml achieved within 6 hours. Enrofloxacin is partly metabolised in the liver. Approximately 45 per cent of the dose is excreted in the urine and 55 per cent in the faeces as active and metabolites.
Overdose: A dose of 25 mg/kg bodyweight administered for 15 consecutive days is tolerated without any clinical symptoms.
Clinical signs seen in gross overdosage include diarrhoea, ataxia, lameness and muscle tremors. In accidental overdosage there is no antidote and treatment should be symptomatic.
7. Baytril Piglet Doser
Enrofloxacin is a synthetic, broad spectrum antimicrobial substance, belonging to the fluoroquinolone group of antibiotics. It is bactericidal in action with activity against Gram positive and Gram negative bacteria and mycoplasmas. The mechanism of action of the quinolones is unique among antimicrobials – they act primarily to inhibit bacterial DNA gyrase, an enzyme responsible for controlling the supercoiling of bacterial DNA during replication. Resealing of the double standard helix is inhibited resulting in irreversible degradation of the chromosomal DNA. The fluoroquinolones also possess activity against bacteria in the stationary phase by an alteration of the permeability of the outer membrane phospholipid cell wall. The pharmacokinetics of enrofloxacin are such that oral and parenteral administration leads to similar serum levels. Enrofloxacin possesses a high distribution volume. Tissue levels 2-3 times higher than that found in the serum have been demonstrated in laboratory animals and target species. Organs in which high levels can be expected are the lungs, liver, kidney, bone and lymphatic system. Enrofloxacin also distributes into the cerebrospinal fluid, the aqueous humour and the foetus in pregnant animals.
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